Rheumatology, Osteoarthritis
21. Dec 2015
Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based cohort of middle-aged women
CONTEXT AND OBJECTIVE:
We evaluated the predictive value of serum cartilage oligomeric matrix protein (sCOMP) levels over 20 years on the development of radiographic (RKOA) and painful knee osteoarthritis (KOA) in a longitudinal cohort of middle-aged women.
MATERIALS AND METHODS:
Five hundred a…
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Authors:
- Kluzek S,
- Bay-Jensen AC,
- Judge A,
- Karsdal MA,
- Shorthose M,
- Spector T,
- Hart D,
- Newton JL,
- Arden NK,
Extracellular Matrix Research
21. Dec 2015
Protein degradation fragments as diagnostic and prognostic biomarkers of connective tissue diseases: understanding the extracellular matrix message and implication for current and future serological biomarkers
The aim of this review is to discuss the potential usefulness of novel biochemical markers of connective tissues: neo-epitopes of extracellular matrix proteins generated by post-translational modifications by tissue proteinases. As each modification results from a specific local physiological or pat…
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Endocrinology
7. Dec 2015
Collagen Type III and VI Turnover in Response to Long-Term Immobilization
BACKGROUND:
Muscle mass and function are perturbed by immobilization and remobilization. When muscle mass changes, the quality and quantity of the extracellular matrix protein, particularly the collagens, change with it. In this study, we investigated the temporal profile of three peptide biomarker…
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Authors:
- Sun S,
- Henriksen K,
- Karsdal MA,
- Byrjalsen I,
- Rittweger J,
- Armbrecht G,
- Belavý DL,
- Felsenberg D,
- Nedergaard AF,
Endocrinology
6. Dec 2015
Collagen fragment biomarkers as serological biomarkers of lean body mass - a biomarker pilot study from the DAHANCA25B cohort and matched controls
BACKGROUND:
Loss of muscle mass and function is an important complication to ageing and a range of pathologies, including, but not restricted to, cancer, organ failures, and sepsis. A number of interventions have been proposed ranging from exercise to anabolic pharmacological therapy, with varying …
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Journal:
Authors:
- Nedergaard A,
- Dalgas U,
- Primdahl H,
- Johansen J,
- Overgaard J,
- Overgaard K,
- Henriksen K,
- Karsdal MA,
- Lønbro S,
Rheumatology, Osteoarthritis
2. Dec 2015
Sensitization and Serological Biomarkers in Knee Osteoarthritis Patients With Different Degrees of Synovitis
OBJECTIVE:
Synovitis is a frequent condition in knee osteoarthritis (KOA) and has been associated with pain. This study investigated the links between the pressure hyperalgesia, the clinical pain, the degree of the synovitis, inflammatory biomarkers, and tissue-specific biomarkers in KOA patients.
…
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Authors:
- Petersen KK,
- Siebuhr AS,
- Graven-Nielsen T,
- Simonsen O,
- Boesen MP,
- Gudbergsen H,
- Karsdal MA,
- Bay-Jensen AC,
- Arendt-Nielsen L,
Cardiovascular System
30. Oct 2015
Postoperative volume balance: does stroke volume increase in Trendelenburg's position?
In healthy humans, stroke volume (SV) and cardiac output (CO) do not increase with expansion of the central blood volume by head-down tilt or administration of fluid. Here, we exposed 85 patients to Trendelenburg's position about one hour after surgery while cardiovascular variables were determined …
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Authors:
- Frost H,
- Mortensen CR,
- Secher NH,
- Nielsen HB,
Bone, Osteoporosis
27. Oct 2015
Role of biochemical markers in the management of osteoporosis
Estrogen and bone health form a cornerstone of osteoporosis management. Diagnosis of osteoporosis is performed using bone mineral density (BMD), despite the limitations associated with this. Within the last 25 years, numerous bone turnover markers (BTM) have been developed, and this has led to a mar…
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Rheumatology, Osteoarthritis
20. Oct 2015
Inflammation (or synovitis)-driven osteoarthritis: an opportunity for personalizing prognosis and treatment?
The disabling and painful disease osteoarthritis (OA) is the most common form of arthritis. Strong evidence suggests that a subpopulation of OA patients has a form of OA driven by inflammation. Consequently, understanding when inflammation is the driver of disease progression and which OA patients m…
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Journal:
Authors:
- Siebuhr AS,
- Bay-Jensen AC,
- Jordan JM,
- Kjelgaard-Petersen CF,
- Christiansen C,
- Abramson SB,
- Attur M,
- Berenbaum F,
- Kraus V,
- Karsdal MA,
Gastrointestinal, Inflammatory Bowel Disease
1. Oct 2015
Fragments of Citrullinated and MMP-degraded Vimentin and MMP-degraded Type III Collagen Are Novel Serological Biomarkers to Differentiate Crohn's Disease from Ulcerative Colitis
BACKGROUND AND AIMS:
A hallmark of inflammatory bowel disease [IBD] is chronic inflammation, which leads to excessive extracellular matrix [ECM] remodelling and release of specific protein fragments, called neoepitopes. We speculated that the biomarker profile panel for ulcerative colitis [UC] and …
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Authors:
- Mortensen JH,
- Godskesen LE,
- Jensen MD,
- Van Haaften WT,
- Klinge LG,
- Olinga P,
- Dijkstra G,
- Kjeldsen J,
- Karsdal MA,
- Bay-Jensen AC,
- Krag A,
Rheumatology, Systemic Sclerosis
1. Oct 2015
Suppression of T Cell Activation and Collagen Accumulation by an Anti-IFNAR1 mAb, Anifrolumab, in Adult Patients with Systemic Sclerosis
Type I IFNs are implicated in the pathophysiology of systemic sclerosis (SSc). Recently, a Phase I open-label trial was conducted with an anti-IFNAR1 receptor antibody (anifrolumab) in adult SSc patients. In this study, we aim to assess the downstream effects of anifrolumab and elucidate the role of…
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Authors:
- Guo X,
- Higgs BW,
- Bay-Jensen AC,
- Karsdal MA,
- Yao Y,
- Roskos LK,
- White WI,
Hepatitis B/C, Hepatic System
25. Sep 2015
Markers of Collagen Remodeling Detect Clinically Significant Fibrosis in Chronic Hepatitis C Patients
BACKGROUND AND AIM:
Detection of advanced fibrosis (Metavir F≥3) is important to identify patients with a high urgency of antiviral treatments vs. those whose treatment could be deferred (F≤2). The aim was to assess the diagnostic value of novel serological extracellular matrix protein fragments as…
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Journal:
Authors:
- Nielsen MJ,
- Kazankov K,
- Leeming DJ,
- Karsdal MA,
- Krag A,
- Barrera F,
- McLeod D,
- George J,
- Grønbæk H,
Bone, Osteoporosis
8. Sep 2015
Null mutation of chloride channel 7 (Clcn7) impairs dental root formation but does not affect enamel mineralization
ClC-7, located in late endosomes and lysosomes, is critical for the function of osteoclasts. Secretion of Cl(-) by the ruffled border of osteoclasts enables H(+) secretion by v-H(+)-ATPases to dissolve bone mineral. Mice lacking ClC-7 show altered lysosomal function that leads to severe lysosomal st…
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Authors:
- Guo J,
- Bervoets TJ,
- Henriksen K,
- Everts V,
- Bronckers AL,
Endocrinology, Type 2-Diabetes
5. Sep 2015
KBP-042 improves bodyweight and glucose homeostasis with indices of increased insulin sensitivity irrespective of route of administration
KBP-042 is a synthetic peptide dual amylin- and calcitonin-receptor agonist (DACRA) developed to treat type 2 diabetes by inducing a significant weight loss while improving glucose homeostasis. In this study the aim was to compare two different formulations: An oral formulation (1mg/kg) to subcutane…
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Authors:
- Hjuler ST,
- Andreassen KV,
- Gydesen S,
- Karsdal MA,
- Henriksen K,
Bone
29. Aug 2015
Two Rare Mutations in the COL1A2 Gene Associate With Low Bone Mineral Density and Fractures in Iceland
We conducted a genome-wide association study of low bone mineral density (BMD) at the hip and spine utilizing sequence variants found through whole-genome sequencing of 2636 Icelanders. We found two rare missense mutations, p.Gly496Ala and p.Gly703Ser, in the COL1A2 gene that associate with measures…
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Authors:
- Styrkarsdottir U,
- Thorleifsson G,
- Eiriksdottir B,
- Gudjonsson SA,
- Ingvarsson T,
- Center JR,
- Nguyen TV,
- Eisman JA,
- Christiansen C,
- Thorsteinsdottir U,
- Sigurdsson G,
- Stefansson K,
Extracellular Matrix Research
22. Aug 2015
Collagen and tissue turnover as function of age - implications for fibrosis
BACKGROUND:
The extracellular matrix (ECM) is the backbone of all tissues. It is a complex grid consisting of multiple structural proteins which each play a vital role for the function and maintenance of normal tissue function. In development and growth, tissue is being formed and elaborated (tissu…
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Authors:
- Karsdal MA,
- Genovese F,
- Madsen EA,
- Manon-Jensen T,
- Schuppan D,
Oncology, Breast, Extracellular Matrix Research
3. Aug 2015
Collagen degradation products measured in serum can separate ovarian and breast cancer patients from healthy controls: A preliminary study
BACKGROUND:
During cancer the otherwise tightly controlled homeostasis of the extracellular matrix (ECM) is disturbed. The protein composition changes, the ECM stiffens and increased levels of proteases are secreted. The combination of these processes result in release of specific protein fragments…
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Journal:
Authors:
- Bager CL,
- Willumsen N,
- Leeming DJ,
- Smith V,
- Karsdal MA,
- Dornan D,
- Bay-Jensen AC,
Rheumatology, Osteoarthritis
1. Aug 2015
Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use
Osteoarthritis (OA) is a heterogeneous disorder. The goals of this review are (1) To stimulate use of standardized nomenclature for OA that could serve as building blocks for describing OA and defining OA phenotypes, in short to provide unifying disease concepts for a heterogeneous disorder; and (2)…
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Authors:
- Kraus VB,
- Blanco FJ,
- Englund M,
- Karsdal MA,
- Lohmander LS,
Alzheimer’s Disease, Central Nervous System
10. Jul 2015
Serum fragments of Tau for the differential diagnosis of Alzheimer's disease
Differential diagnosis of AD is still a challenge due to overlapping features with other types of dementia. Biomarkers for the differential diagnosis of AD can improve the diagnostic value of the disease and ensure an appropriate treatment of patients. The aim of this study was to evaluate the poten…
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Authors:
- Inekci D,
- Henriksen K,
- Linemann T,
- Karsdal MA,
- Habib A,
- Bisgaard, C,
- Eriksen FB,
- Vilholm OJ,
Respiratory System, Idiopathic Pulmonary Fibrosis
9. Jul 2015
Levels of circulating MMP-7 degraded elastin are elevated in pulmonary disorders
OBJECTIVES:
Elastin is a signature protein of the lungs. Matrix metalloproteinase-7 (MMP-7) is important in lung defence mechanisms and degrades elastin. However, MMP-7 activity in regard to elastin degradation has never been quantified serologically in patients with lung diseases. An assay for the…
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Journal:
Authors:
- Kristensen JH,
- Larsen L,
- Dasgupta B,
- Brodmerkel C,
- Curran M,
- Karsdal MA,
- Sand JM,
- Willumsen N,
- Knox AJ,
- Bolton CE,
- Johnson SR,
- Hägglund P,
- Svensson B,
- Leeming DJ,
Hepatic System, Non-Alcoholic Fatty Liver Disease
3. Jul 2015
Circulating Elastin Fragments Are Not Affected by Hepatic, Renal and Hemodynamic Changes, But Reflect Survival in Cirrhosis with TIPS
BACKGROUND AND AIMS:
Progressive fibrosis increases hepatic resistance and causes portal hypertension with complications. During progressive fibrosis remodeling and deposition of collagens and elastin occur. Elastin remodeling is crucially involved in fibrosis progression in animal models and human…
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Journal:
Authors:
- Nielsen MJ,
- Lehmann J,
- Leeming DJ,
- Schierwagen R,
- Klein S,
- Jansen C,
- Strassburg CP,
- Bendtsen F,
- Møller S,
- Sauerbruch T,
- Karsdal MA,
- Krag A,
- Trebicka J,
Respiratory System, Chronic Obstructive Pulmonary Disease
1. Jul 2015
Clinical Drug Development Using Dynamic Biomarkers to Enable Personalized Health Care in COPD
Despite massive investments in the development of novel treatments for heterogeneous diseases such as COPD, the resources spent have only benefited a fraction of the population treated. Personalized health care to guide selection of a suitable patient population already in the clinical development o…
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Journal:
Authors:
- Bihlet A,
- Karsdal MA,
- Bay-Jensen AC,
- Read S,
- Kristensen JH,
- Sand JM,
- Leeming DJ,
- Andersen JR,
- Lange P,
- Vestbo J,
Renal System, Chronic Renal Disease
1. Jul 2015
Serum and urine markers of collagen degradation reflect renal fibrosis in experimental kidney diseases
BACKGROUND:
The extent of renal fibrosis in chronic kidney disease (CKD) is the best predictor for progression of most renal diseases. To date, no established biomarkers of renal fibrosis exist.
METHODS:
We measured circulating and urinary-specific matrix metalloproteinase (MMP)-generated colla…
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Journal:
Authors:
- Papasotiriou M,
- Genovese F,
- Klinkhammer BM,
- Kunter U,
- Nielsen SH,
- Karsdal MA,
- Floege J,
- Boor P,
Bone, Osteoporosis
1. Jul 2015
Suppressed bone remodeling in black bears conserves energy and bone mass during hibernation
Decreased physical activity in mammals increases bone turnover and uncouples bone formation from bone resorption, leading to hypercalcemia, hypercalcuria, bone loss and increased fracture risk. Black bears, however, are physically inactive for up to 6 months annually during hibernation without losin…
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Authors:
- McGee-Lawrence M,
- Buckendahl P,
- Carpenter C,
- Henriksen K,
- Vaughan M,
- Donahue S,
Alzheimer’s Disease, Central Nervous System
11. Jun 2015
Relationship between serum levels of tau fragments and clinical progression of Alzheimer's disease
Enzyme-generated fragments of tau have been linked to neuronal death and may serve as serum biomarkers of cognitive loss. Two competitive ELISAs detecting an ADAM10-generated fragment (Tau-A) or a caspase-3-generated fragment (Tau-C) were measured in baseline serum samples from patients with mild to…
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Chronic Obstructive Pulmonary Disease, Respiratory System
11. Jun 2015
Accelerated extracellular matrix turnover during exacerbations of COPD
BACKGROUND:
Exacerbations of chronic obstructive pulmonary disease (COPD) contribute significantly to disease progression. However, the effect on tissue structure and turnover is not well described. There is an urgent clinical need for biomarkers of disease activity associated with disease progress…
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Journal:
Authors:
- Sand JM,
- Knox AJ,
- Lange P,
- Sun S,
- Kristensen JH,
- Leeming DJ,
- Karsdal MA,
- Bolton CE,
- Johnson SR,
1. Jun 2015
Longitudinal change in collagen degradation biomarkers in idiopathic pulmonary fibrosis: an analysis from the prospective, multicentre PROFILE study
BACKGROUND:
Idiopathic pulmonary fibrosis, a progressive and inevitably fatal disorder, has a highly variable clinical course. Biomarkers that reflect disease activity are urgently needed to inform patient management and for use as biomarkers of therapeutic response (theragnostic biomarkers) in cli…
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Journal:
Authors:
- Jenkins RG,
- Simpson JK,
- Saini G,
- Bentley JH,
- Russell AM,
- Braybrooke R,
- Molyneaux PL,
- McKeever TM,
- Wells AU,
- Flynn A,
- Hubbard RB,
- Leeming DJ,
- Marshall RP,
- Karsdal MA,
- Lukey PT,
- Maher TM,
Hepatic System, Non-Alcoholic Fatty Liver Disease
15. May 2015
Novel insights into the function and dynamics of extracellular matrix in liver fibrosis
Emerging evidence suggests that altered components and posttranslational modifications of proteins in the extracellular matrix (ECM) may both initiate and drive disease progression. The ECM is a complex grid consisting of multiple proteins, most of which play a vital role in containing the essential…
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Authors:
- Karsdal MA,
- Manon-Jensen T,
- Genovese F,
- Kristensen JH,
- Nielsen MJ,
- Sand JM,
- Hansen NU,
- Bay-Jensen AC,
- Bager CL,
- Krag A,
- Blanchard A,
- Krarup H,
- Leeming DJ,
- Schuppan D,
Central Nervous System, Alzheimer’s Disease
11. May 2015
Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research
The lack of readily available biomarkers is a significant hindrance toward progressing to effective therapeutic and preventative strategies for Alzheimer's disease (AD). Blood-based biomarkers have potential to overcome access and cost barriers and greatly facilitate advanced neuroimaging and cerebr…
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Journal:
Authors:
- O'Bryant SE,
- Gupta V,
- Henriksen K,
- Edwards M,
- Jeromin A,
- Lista S,
- Bazenet C,
- Soares H,
- Lovestone S,
- Hampel H,
- Montine T,
- Blennow K,
- Carrillo M,
- Graff-Radford N,
- Laske C,
- Breteler M,
- Shaw L,
- Trojanowski JQ,
- Schupf N,
- Rissman RA,
- Fagan AM,
- Oberoi P,
- Umek R,
- Weiner MW,
- Grammas P,
- Posner H,
- Martins R,
- STAR-B and BBBIG working groups,
Alzheimer’s Disease, Central Nervous System
11. May 2015
The potential of pathological protein fragmentation in blood-based biomarker development for dementia - with emphasis on Alzheimer's disease
The diagnosis of dementia is challenging and early stages are rarely detected limiting the possibilities for early intervention. Another challenge is the overlap in the clinical features across the different dementia types leading to difficulties in the differential diagnosis. Identifying biomarkers…
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Journal:
Authors:
- Inekci D,
- Jonesco DS,
- Kennard S,
- Karsdal MA,
- Henriksen K,
Bone, Osteoporosis
10. May 2015
Novel targets for the prevention of osteoporosis - lessons learned from studies of metabolic bone disorders
Osteoporosis is a major health care problem, and whereas efficacious treatments for vertebral fracture reduction are available for osteoporosis patients, these therapies are still limited with respect to capacity for restoration of bone loss, as well as efficacy on non-vertebral fractures, such as h…
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Authors:
Respiratory System, Chronic Obstructive Pulmonary Disease
3. May 2015
Serological assessment of neutrophil elastase activity on elastin during lung ECM remodeling
BACKGROUND:
During the pathological destruction of lung tissue, neutrophil elastase (NE) degrades elastin, one of the major constituents of lung parenchyma. However there are no non-invasive methods to quantify NE degradation of elastin. We selected specific elastin fragments generated by NE for an…
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Journal:
Authors:
- Kristensen JH,
- Karsdal MA,
- Sand JM,
- Willumsen N,
- Diefenbach C,
- Svensson B,
- Hägglund P,
- Oersnes-Leeming DJ,
Hepatic System, Alcoholic Liver Disease
1. May 2015
Pro-C5, a marker of true type V collagen formation and fibrillation, correlates with portal hypertension in patients with alcoholic cirrhosis
BACKGROUND AND AIMS:
The hepatic venous pressure gradient (HVPG) is an important but invasive diagnostic and prognostic marker in cirrhotic patients. The aim of the study was to evaluate a novel biochemical plasma marker of true type V collagen formation (Pro-C5) for describing HVPG.
METHODS:
N…
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Journal:
Authors:
- Leeming DJ,
- Veidal SS,
- Karsdal MA,
- Nielsen MJ,
- Trebicka J,
- Busk T,
- Bendtsen F,
- Krag A,
- Møller S,
Endocrinology, Type 2-Diabetes
1. May 2015
Lessons learned from the clinical development of oral peptides
The oral delivery of peptides and proteins has been hampered by an array of obstacles. However, several promising novel oral delivery systems have been developed. This paper reviews the most advanced oral formulation technologies, and highlights key lessons and implications from studies undertaken t…
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Journal:
Authors:
- Karsdal MA,
- Riis BJ,
- Mehta N,
- Stern W,
- Arbit E,
- Christiansen C,
- Henriksen K,
Extracellular Matrix Research
30. Apr 2015
Matrix Metalloproteinase Mediated Type I Collagen Degradation - An Independent Risk Factor for Mortality in Women
Chronic fibro-proliferative diseases are associated with nearly 45% of all deaths in the developed world. Matrix metalloproteinase (MMP) mediated remodeling of the extracellular matrix (ECM) plays an important role in disease development. Degradation of type I collagen is considered having a major r…
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Journal:
Authors:
- Dragsbæk K,
- Neergaard JS,
- Hansen HB,
- Byrjalsen I,
- Alexandersen P,
- Kehlet SN,
- Bay-Jensen AC,
- Christiansen C,
- Karsdal MA,
Extracellular Matrix Research, Renal System, Chronic Renal Disease
26. Apr 2015
Turnover of type III collagen reflects disease severity and is associated with progression and microinflammation in patients with IgA nephropathy
BACKGROUND:
Renal fibrosis is the hallmark of progression to end-stage kidney disease. Non-invasive biomarkers of renal fibrosis could serve as specific end points in clinical trials and improve monitoring and stratification of patients with chronic kidney disease (CKD). To address this, we measure…
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Journal:
Authors:
- Genovese F,
- Boor P,
- Papasotiriou M,
- Leeming DJ,
- Karsdal MA,
- Floege J,
Rheumatology, Osteoarthritis
24. Apr 2015
The effect of protease inhibitors on the induction of osteoarthritis-related biomarkers in bovine full-depth cartilage explants
OBJECTIVE:
The specific degradation of type II collagen and aggrecan by matrix metalloproteinase (MMP)-9, -13 and ADAMTS-4 and -5 (aggrecanase-1 and -2) in the cartilage matrix is a critical step in pathology of osteoarthritis (OA). The aims of this study were: i) To investigate the relative contri…
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Journal:
Authors:
- He Y,
- Zheng Q,
- Jiang M,
- Christiansen TG,
- Kassem M,
- Karsdal MA,
- Bay-Jensen AC,
Clinical Data Quality
1. Apr 2015
Impact of source data verification on data quality in clinical trials: an empirical post hoc analysis of three phase 3 randomized clinical trials
AIM:
The aim of this project was to perform an empirical evaluation of the impact of on site source data verification (SDV) on the data quality in a clinical trial database to guide an informed decision on selection of the monitoring approach.
METHODS:
We used data from three randomized phase I…
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Journal:
Authors:
- Andersen JR,
- Byrjalsen I,
- Bihlet A,
- Kalakou F,
- Hoeck HC,
- Hansen G,
- Hansen HB,
- Karsdal MA,
- Riis BJ,
Rheumatology, Osteoarthritis
1. Apr 2015
OA phenotypes, rather than disease stage, drive structural progression--identification of structural progressors from 2 phase III randomized clinical studies with symptomatic knee OA
BACKGROUND/PURPOSE:
The aim of this study was to identify key characteristics of disease progression through investigation of the association of radiographic progression over two years with baseline Joint Space Width (JSW), Kellgren-Lawrence (KL) grade, Western Ontario and McMaster Universities Art…
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Journal:
Authors:
- Karsdal MA,
- Bihlet A,
- Byrjalsen I,
- Alexandersen P,
- Ladel C,
- Michaels M,
- Andersen JR,
- Riis BJ,
- Kraus V,
- Bay-Jensen AC,
- Christiansen C,
Extracellular Matrix Research
1. Apr 2015
The importance of extracellular matrix for cell function and in vivo likeness
OBJECTIVE:
Fibrotic diseases may be described as a disease of the extracellular matrix, where the balance between matrix formation and degradation has been shifted leading to an accumulation of matrix. Currently a fit for purpose model and readily available approach are adapted when doing cell cult…
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Journal:
Authors:
- Hansen NU,
- Genovese F,
- Leeming DJ,
- Karsdal MA,
Rheumatology, Osteoarthritis
1. Apr 2015
Treatment of symptomatic knee osteoarthritis with oral salmon calcitonin: results from two phase 3 trials
PURPOSE:
To evaluate the structure-modifying and symptom efficacy, as well as safety and tolerability of oral salmon calcitonin (sCT) formulated with a 5-CNAC carrier (a molecule based on Eligen(®) technology), in osteoarthritis (OA) patients with moderate to severe knee pain and joint structural d…
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Journal:
Authors:
- Karsdal MA,
- Byrjalsen I,
- Alexandersen P,
- Bihlet A,
- Andersen JR,
- Riis BJ,
- Bay-Jensen AC,
- Christiansen C,
- CSMC021C2301/1 investigators,
Rheumatology, Alkaptonuria
1. Mar 2015
Twelve novel HGD gene variants identified in 99 alkaptonuria patients: focus on 'black bone disease' in Italy
Alkaptonuria (AKU) is an autosomal recessive disorder caused by mutations in homogentisate-1,2-dioxygenase (HGD) gene leading to the deficiency of HGD enzyme activity. The DevelopAKUre project is underway to test nitisinone as a specific treatment to counteract this derangement of the phenylalanine-…
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Journal:
Authors:
- Nemethova M,
- Radvanszky J,
- Kadasi L,
- Ascher DB,
- Pires DE,
- Blundell TL,
- Porfirio B,
- Mannoni A,
- Santucci A,
- Milucci L,
- Sestini S,
- , Biolcati G,
- Sorge,
- Aurizi C,
- Aquaron R,
- Alsbou M,
- Marques Lourenço C,
- Ramadevi K,
- Ranganath LR,
- Gallagher JA,
- van Kan C,
- Hall AK,
- Olsson B,
- Ayoob H,
- Timmis OG,
- Le Quan Sang KH,
- Genovese F,
- Imrich R,
- Rovensky J,
- Srinivasaraghavan R,
- Bharadwaj SK,
- Spiegel R,
- Zatkova A,
Extracellular Matrix Research, Hepatitis B/C, Hepatic System
1. Feb 2015
Plasma Pro-C3 (N-terminal type III collagen propeptide) predicts fibrosis progression in patients with chronic hepatitis C
BACKGROUND & AIMS:
Fibrogenesis results in release of certain extracellular matrix protein fragments into the circulation. We evaluated the diagnostic and prognostic performance of two novel serological markers, the precisely cleaved N-terminal propeptide of type III collagen (Pro-C3) and a peptide…
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Journal:
Authors:
- Nielsen MJ,
- Veidal SS,
- Karsdal MA,
- Leeming DJ,
- Vainer B,
- Gardner SD,
- Hamatake R,
- Goodman ZD,
- Schuppan D,
- Patel K,
1. Feb 2015
The collagen turnover profile is altered in patients with inguinal and incisional hernia
BACKGROUND:
Disturbed metabolism in the extracellular matrix (ECM) contributes to formation of abdominal wall hernias. The aim of this study was to gain deeper insight into the ECM turnover in hernia patients by analyzing serum biomarkers specifically reflecting collagen synthesis and breakdown in …
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Journal:
Authors:
- Henriksen NA,
- Mortensen JH,
- Sorensen LT,
- Bay-Jensen AC,
- Ågren MS,
- Jorgensen LN,
- Karsdal MA,
Rheumatology, Osteoarthritis
1. Jan 2015
Association between biochemical cartilage markers and clinical symptoms in patients with hip osteoarthritis: cohort study with 2-year follow-up
OBJECTIVES:
To assess associations between uCTX-II or uCIIM and severity of hip pain in patients with mild-moderate hip osteoarthritis (OA) over a 2-year period, and establish whether the level of these biomarkers at baseline could estimate a specific trajectory of hip pain.
DESIGN:
A cohort st…
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Journal:
Authors:
- Dorleijn DM,
- Luijsterburg PA,
- Bay-Jensen AC,
- Siebuhr AS,
- Karsdal MA,
- Rozendaal RM,
- Bos PK,
- Bierma-Zeinstra SM,
Rheumatology, Gout
1. Jan 2015
Investigating the Robustness and Diagnostic Potential of Extracellular Matrix Remodelling Biomarkers in Alkaptonuria
BACKGROUND AND AIM:
Alkaptonuria (AKU) clinical manifestations resemble severe arthritis. The Suitability of Nitisinone in Alkaptonuria 1 (SONIA 1) study is a dose-finding trial for nitisinone treatment of AKU patients. We tested a panel of serum and urinary biomarkers reflecting extracellular matr…
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Journal:
Authors:
- Genovese F,
- Siebuhr AS,
- Musa K,
- Gallagher JA,
- Milan AM,
- Karsdal MA,
- Rovensky J,
- Bay-Jensen AC,
- Ranganath LR,
Rheumatology, Osteoarthritis
1. Jan 2015
Identifying specific profiles in patients with different degrees of painful knee osteoarthritis based on serological biochemical and mechanistic pain biomarkers: a diagnostic approach based on cluster analysis
Biochemical and pain biomarkers can be applied to patients with painful osteoarthritis profiles and may provide more details compared with conventional clinical tools. The aim of this study was to identify an optimal combination of biochemical and pain biomarkers for classification of patients with …
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Journal:
Authors:
- Egsgaard LL,
- Eskehave TN,
- Bay-Jensen AC,
- Hoeck HC,
- Arendt-Nielsen L,