Bone
16. May 2004
Characterization of osteoclasts from patients harboring a G215R mutation in ClC-7 causing autosomal dominant osteopetrosis type II
Autosomal dominant osteopetrosis II (ADOII) is a relatively benign disorder caused by a missense mutation in the ClCN7 gene. In this study, we characterize the osteoclasts from patients with ADOII, caused by a G215R mutation, and investigate the effect on osteoclast function in vitro. Osteoclasts fr…
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Journal:
Authors:
- Henriksen K,
- Gram J,
- Schaller S,
- Dahl BH,
- Dziegiel MH,
- Bollerslev J,
- Karsdal MA,
Bone
23. Mar 2004
Matrix metalloproteinases (MMPs) safeguard osteoblasts from apoptosis during transdifferentiation into osteocytes: MT1-MMP maintains osteocyte viability
Osteoblasts undergo apoptosis or differentiate into either osteocytes or bone-lining cells after termination of bone matrix synthesis. In this study, we investigated the role of matrix metalloproteinases (MMPs) in differentiation of osteoblasts, bone formation, transdifferentiation into osteocytes, …
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Journal:
Authors:
- Karsdal MA,
- Andersen TA,
- Bonewald L,
- Christiansen C,
Bone
1. Mar 2004
The chloride channel inhibitor NS3736 [corrected] prevents bone resorption in ovariectomized rats without changing bone formation
Chloride channel activity is essential for osteoclast function. Consequently, inhibition of the osteoclastic chloride channel should prevent bone resorption. Accordingly, we tested a chloride channel inhibitor on bone turnover and found that it inhibits bone resorption without affecting bone formati…
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Journal:
Authors:
- Schaller S,
- Henriksen K,
- Sveigaard C,
- Heegaard AM,
- Hélix N,
- Stahlhut M,
- Ovejero MC,
- Johansen JV,
- Solberg H,
- Andersen TL,
- Hougaard D,
- Berryman M,
- Shiødt CB,
- Sørensen BH,
- Lichtenberg J,
- Christophersen P,
- Foged NT,
- Delaissé JM,
- Engsig MT,,
- Karsdal MA,
Bone
21. Jan 2004
Measurement of tumor load and distribution in a model of cancer-induced osteolysis: a necessary precaution when testing novel anti-resorptive therapies
The Arguello model of cancer metastasis to bone has been used extensively to study breast cancer-induced osteolytic disease. The effects of therapy on skeletal disease and on tumour burden in soft organs are traditionally measured using radiography and/or time-consuming histomorphometry, respectivel…
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Journal:
Authors:
- Amhlaoibh RN,
- Hoegh-Andersen P,
- Brünner N,
- Sørensen A,
- Winding B,
- Holst-Hansen C,
- Karsdal MA,
- Engsig MT,
- Delaissé JM,
- Heegaard AM,