Bone
23. Sep 2003
RANKL and vascular endothelial growth factor (VEGF) induce osteoclast chemotaxis through an ERK1/2-dependent mechanism
Development of bone depends on a continuous supply of bone-degrading osteoclasts. Although several factors such as the matrix metalloproteinases and the integrins have been shown to be important for osteoclast recruitment, the mechanism of action remains poorly understood. In this study we investiga…
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Journal:
Authors:
- Henriksen K,
- Karsdal MA,
- Delaisse JM,
- Engsig MT,
Bone
20. Aug 2003
Transforming growth factor-beta controls human osteoclastogenesis through the p38 MAPK and regulation of RANK expression
Although RANK-L is essential for osteoclast formation, factors such as transforming growth factor-beta (TGF-beta) are potent modulators of osteoclastogenic stimuli. To systematically investigate the role of TGF-beta in human osteoclastogenesis, monocytes were isolated from peripheral blood by three …
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Journal:
Authors:
- Karsdal MA,
- Hjorth P,
- Henriksen K,
- Kirkegaard T,
- Nielsen KL,
- Lou H,
- Delaissé JM,
- Foged NT,
Bone
1. May 2003
The type I collagen fragments ICTP and CTX reveal distinct enzymatic pathways of bone collagen degradation
Bone resorption may generate collagen fragments such as ICTP and CTX, which can be quantified in serum and/or urine by using specific immunoassays, and which are used as clinical markers. However, the relative abundance of ICTP and CTX varies according to the type of bone pathology, suggesting that …
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Journal:
Authors:
- Garnero P,
- Ferreras M,
- Karsdal MA,
- Nicamhlaoibh R,
- Risteli J,
- Borel O,
- Qvist P,
- Delmas PD,
- Foged NT,
- Delaissé JM,