Bone
10. Sep 2002
Matrix metalloproteinase-dependent activation of latent transforming growth factor-beta controls the conversion of osteoblasts into osteocytes by blocking osteoblast apoptosis
Upon termination of bone matrix synthesis, osteoblasts either undergo apoptosis or differentiate into osteocytes or bone lining cells. In this study, we investigated the role of matrix metalloproteinases (MMPs) and growth factors in the differentiation of osteoblasts into osteocytes and in osteoblas…
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Journal:
Authors:
- Karsdal MA,
- Larsen L,
- Engsig MT,
- Lou H,
- Ferreras M,
- Lochter A,
- Delaissé JM,
- Foged NT,
Rheumatology, Spondyloarthropathies
18. Jan 2002
Matrix metalloproteinase inhibitor BB-3103 unlike the serine proteinase inhibitor aprotinin abrogates epidermal healing of human skin wounds ex vivo
Several matrix metalloproteinases and serine proteinases are upregulated in migrating keratinocytes during cutaneous wound repair. Single cell culture studies indicate the necessity for matrix metalloproteinases but not for serine proteinases in keratinocyte locomotion. To account for epithelial-mes…
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Journal:
Authors:
- Mirastschijski U,
- Impola U,
- Karsdal MA,
- Saarialho-Kere U,
- Agren MS,