Respiratory System, Extracellular Matrix Research
4. May 2018
A Serological Biomarker of Versican Degradation is Associated with Mortality Following Acute Exacerbations of Idiopathic Interstitial Pneumonia
BACKGROUND:
Idiopathic interstitial pneumonia (IIP) is characterized by an increased rate of extracellular matrix (ECM) remodeling resulting in fibrosis. Acute exacerbations of IIP represent periods of increased disease activity, thus we hypothesized that ECM remodeling was altered during acute exa…
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Authors:
- Sand JMB,
- Tanino Y,
- Karsdal MA,
- Nikaido T,
- Misa K,
- Sato Y,
- Togawa R,
- Wang X,
- Leeming DJ,
- Munakata M,
Extracellular Matrix Research
19. Jan 2017
Biomarkers of extracellular matrix turnover are associated with emphysema and eosinophilic-bronchitis in COPD
BACKGROUND:
Chronic obstructive pulmonary disease (COPD) is characterized by airflow obstruction and loss of lung tissue mainly consisting of extracellular matrix (ECM). Three of the main ECM components are type I collagen, the main constituent in the interstitial matrix, type VI collagen, and elas…
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Journal:
Authors:
- Bihlet AR,
- Karsdal MA,
- Sand JM,
- Leeming DJ,
- Roberts M,
- Bowler R,
- White W,
Extracellular Matrix Research, Respiratory System
5. Jul 2016
Tissue turnover of collagen type I, III and elastin is elevated in the PCLS model of IPF and can be restored back to vehicle levels using a phosphodiesterase inhibitor
BACKGROUND:
The aim of this study was to develop and validate a model for pulmonary fibrosis, using ex vivo tissue cultures of lungs from bleomycin treated animals, enabling the investigation of fibrosis remodeling using novel biomarkers for the detection of ECM protein fragments. The combination …
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Journal:
Authors:
- Hansen NU,
- Karsdal MA,
- Brockbank S,
- Cruwys S,
- Rønnow S,
- Christiansen C,