Idiopathic Pulmonary Fibrosis, Respiratory System, Oncology, Lung, Extracellular Matrix Research
2. Jan 2019
The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis.
Myofibroblasts are the key effector cells responsible for excessive extracellular matrix deposition in multiple fibrotic conditions, including idiopathic pulmonary fibrosis (IPF). The PI3K/Akt/mTOR axis has been implicated in fibrosis, with pan-PI3K/mTOR inhibition currently under clinical evaluatio…
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Authors:
- Woodcock HV,
- Eley JD,
- Platé M,
- Manthakumar CB,
- Martufi M,
- Peace S,
- Joberty G,
- Poeckel D,
- Good RB,
- Taylor AR,
- Zinn N,
- Redding M,
- Forty EJ,
- Hynds RE,
- Santon C,
- Karsdal MA,
- Maher TM,
- Bergamini G,
- Marshall RP,
- Blanchard AD,
- Mercer PF,
- Chambers RC,