Bone
5. Apr 2012
Generation of human osteoclasts from peripheral blood
Osteoclasts are multi-nucleated cells that have the unique ability to resorb calcified bone matrix. They derive from haematopoietic precursor cells, and can be generated in vitro by stimulation of peripheral blood mononuclear cells with the cytokines M-CSF and RANKL. In this chapter, we describe the…
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Authors:
- Henriksen K,
- Karsdal MA,
- Taylor A,
- Tosh D,
- Coxon FP,