Cardiovascular System, Myocardial Fibrosis, Acute Myocardial Infarct, Extracellular Matrix Research
19. Nov 2018
Cathepsin K-deficiency impairs mouse cardiac function after myocardial infarction.
BACKGROUND:
Extracellular matrix metabolism and cardiac cell death participate centrally in myocardial infarction (MI). This study tested the roles of collagenolytic cathepsin K (CatK) in post-MI left ventricular remodeling.
METHODS AND RESULTS:
Patients with acute MI had higher plasma CatK lev…
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Authors:
- Fang W,
- He A,
- Xiang MX,
- Lin Y,
- Wang Y,
- Li J,
- Yang C,
- Zhang X,
- Liu CL,
- Sukhova GK,
- Barascuk N,
- Larsen L,
- Karsdal MA,
- Libby P,
- Shi GP,