Cardiovascular System, Extracellular Matrix Research, Atherosclerosis
1. May 2020
Exploring the Role of Extracellular Matrix Proteins to Develop Biomarkers of Plaque Vulnerability and Outcome
Cardiovascular disease (CVD) is the most common cause of death in industrialized countries. One underlying cause is atherosclerosis, which is a systemic disease characterized by plaques of retained lipids, inflammatory cells, apoptotic cells, calcium and extracellular matrix (ECM) proteins in the ar…
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Journal:
Authors:
- Nielsen SH,
- Jonasson L,
- Kalogeropoulos K,
- Karsdal MA,
- Reese-Petersen AL,
- Auf dem Keller U,
- Genovese F,
- Nilsson J,
- Goncalves I,
Cardiovascular System, Atherosclerosis, Extracellular Matrix Research, Biomarker position
28. Aug 2018
A biomarker of collagen type I degradation is associated with cardiovascular events and mortality in patients with atherosclerosis.
OBJECTIVE:
Atherosclerosis is characterized by accumulation of lipids, cells and extracellular matrix (ECM) proteins in the arterial wall. Collagen type I (COL1), a component of the arterial ECM, is cleaved by matrix metalloproteinases (MMPs) and known to be remodelled in atherosclerosis. We explor…
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Journal:
Authors:
- Holm Nielsen S,
- Tengryd C,
- Edsfeldt A,
- Genovese F,
- Bengtsson E,
- Karsdal MA,
- Leeming DJ,
- Nilsson J,
- Goncalves I,