Extracellular Matrix Research
9. Oct 2014
Measurement of a MMP-2 degraded Titin fragment in serum reflects changes in muscle turnover induced by atrophy
PURPOSE:
In this study we sought to determine whether a Titin peptide fragment can serve as a clinical biomarker for changes in muscle mass.
METHODS:
Mass spectrometry was used to identify Titin fragment in urine. An antibody against this Titin sequence was raised and used to develop a competit…
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Journal:
Authors:
- Sun S,
- Henriksen K,
- Karsdal MA,
- Armbrecht G,
- Belavý DL,
- Felsenberg D,
- Rittweger J,
- Wang Y,
- Zheng Q,
- Nedergaard AF,