Rheumatology, Osteoarthritis
5. May 2016
The Need for Predictive, Prognostic, Objective and Complementary Blood-Based Biomarkers in Osteoarthritis (OA)
Osteoarthritis (OA) has traditionally been viewed as a non-inflammatory arthropathy and has not been considered a ‘serious disease’. However, this view has radically changed in recent years, due to the complexity and heterogeneity of the patient populations, spiralling socio-economical costs and lon…
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Journal:
Authors:
- Bay-Jensen AC,
- Henrotin Y,
- Karsdal MA,
- Mobasheri A,
Extracellular Matrix Research
30. Apr 2015
Matrix Metalloproteinase Mediated Type I Collagen Degradation - An Independent Risk Factor for Mortality in Women
Chronic fibro-proliferative diseases are associated with nearly 45% of all deaths in the developed world. Matrix metalloproteinase (MMP) mediated remodeling of the extracellular matrix (ECM) plays an important role in disease development. Degradation of type I collagen is considered having a major r…
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Journal:
Authors:
- Dragsbæk K,
- Neergaard JS,
- Hansen HB,
- Byrjalsen I,
- Alexandersen P,
- Kehlet SN,
- Bay-Jensen AC,
- Christiansen C,
- Karsdal MA,