Rheumatology, Rheumatoid Arthritis
18. Apr 2018
Translational Biomarkers and Ex Vivo Models of Joint Tissues as a Tool for Drug Development in Rheumatoid Arthritis
OBJECTIVE:
Rheumatoid arthritis (RA) is a chronic, autoimmune and degenerative joint disease leading to disability, reduced life quality, and increased mortality. Although several synthetic and biological disease modifying anti-rheumatic drugs (DMARDs) are available, there is still a medical need f…
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Journal:
Authors:
- Kjelgaard-Petersen CF,
- Platt A,
- Braddock M,
- Jenkins MA,
- Musa K,
- Graham E,
- Gantzel T,
- Slynn G,
- Weinblatt ME,
- Karsdal MA,
- Thudium CS,
- Bay-Jensen AC,
Rheumatology, Osteoarthritis
11. Dec 2014
Association between experimental pain biomarkers and serologic markers in patients with different degrees of painful knee osteoarthritis
OBJECTIVE:
To assess the association between pain mechanisms (sensitization) and biochemical markers for cartilage, bone, and inflammation in patients with knee pain.
METHODS:
The study group comprised 281 patients with different degrees of knee pain intensity and radiographic findings (using t…
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Journal:
Authors:
- Arendt-Nielsen L,
- Eskehave TN,
- Egsgaard LL,
- Petersen KK,
- Graven-Nielsen T,
- Hoeck HC,
- Simonsen O,
- Siebuhr AS,
- Karsdal MA,
- Bay-Jensen AC,
Osteoarthritis
1. Sep 2014
Alpha C-telopeptide of type I collagen is associated with subchondral bone turnover and predicts progression of joint space narrowing and osteophytes in osteoarthritis
OBJECTIVE:
To evaluate joint tissue remodeling using the urinary collagen biomarkers urinary α-C-telopeptide of type I collagen (α-CTX) and urinary C-telopeptide of type II collagen (CTX-II) and to determine the association of these biomarkers with osteoarthritis (OA) severity, progression, and loc…
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Journal:
Authors:
- Huebner JL,
- Bay-Jensen AC,
- Huffman K,
- He Y,
- Leeming DJ,
- McDaniel GE,
- Karsdal MA,
- Kraus VB,
Rheumatology, Osteoarthritis
28. Aug 2014
Association Between Experimental Pain Biomarkers and Serological Markers in Patients With Different Degree of Painful Knee Osteoarthritis
OBJECTIVE:
To assess the association between pain mechanisms (sensitization) and biochemical markers for cartilage, bone, and inflammation in patients with knee pain.
METHODS:
The study group comprised 281 patients with different degrees of knee pain intensity and radiographic findings (using t…
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Journal:
Authors:
- Arendt-Nielsen L,
- Eskehave TN,
- Egsgaard LL,
- Petersen KK,
- Graven-Nielsen T,
- Hoeck HC,
- Simonsen O,
- Siebuhr AS,
- Karsdal MA,
- Bay-Jensen AC,
Bone, Rheumatology, Osteoarthritis
6. Jun 2014
ALPHA-CTX is associated with subchondral bone turnover and predicts progression of joint space narrowing and osteophytes in osteoarthritis
OBJECTIVE:
To evaluate joint tissue remodeling, with urinary collagen biomarkers, uALPHA CTX and uCTXII, and their association with osteoarthritis (OA) severity, progression, and localized knee bone turnover.
METHODS:
Participants (N=149) with symptomatic and radiographic knee OA underwent fixe…
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Journal:
Authors:
- Huebner JL,
- Bay-Jensen AC,
- Huffman KM,
- He Y,
- Leeming DJ,
- McDaniel GE,
- Karsdal MA,
- Kraus VB,