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Rheumatology, Osteoarthritis
2. Feb 2010

Biglycan and fibromodulin have essential roles in regulating chondrogenesis and extracellular matrix turnover in temporomandibular joint osteoarthritis

The temporomandibular joint is critical for jaw movements and allows for mastication, digestion of food, and speech. Temporomandibular joint osteoarthritis is a degenerative disease that is marked by permanent cartilage destruction and loss of extracellular matrix (ECM). To understand how the ECM re…

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Authors:

  • Embree MC,
  • Kilts TM,
  • Ono M,
  • Inkson CA,
  • Syed-Picard F,
  • Karsdal MA,
  • Oldberg A,
  • Bi Y,
  • Young MF,
Bone
5. Nov 2005

Osteoclasts from patients with autosomal dominant osteopetrosis type I caused by a T253I mutation in low-density lipoprotein receptor-related protein 5 are normal in vitro, but have decreased resorption capacity in vivo

Autosomal dominant osteopetrosis type I (ADOI) is presumably caused by gain-of-function mutations in the LRP5 gene. Patients with a T253I mutation in LRP5 have a high bone mass phenotype, characterized by increased mineralizing surface index but abnormally low numbers of small osteoclasts. To invest…

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Authors:

  • Henriksen K,
  • Gram J,
  • Høegh-Andersen P,
  • Jemtland R,
  • Ueland T,
  • Dziegiel MH,
  • Schaller S,
  • Bollerslev J,
  • Karsdal MA,
Bone
5. Feb 2005

Acidification of the osteoclastic resorption compartment provides insight into the coupling of bone formation to bone resorption

Patients with defective osteoclastic acidification have increased numbers of osteoclasts, with decreased resorption, but bone formation that remains unchanged. We demonstrate that osteoclast survival is increased when acidification is impaired, and that impairment of acidification results in inhibit…

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Bone
16. May 2004

Characterization of osteoclasts from patients harboring a G215R mutation in ClC-7 causing autosomal dominant osteopetrosis type II

Autosomal dominant osteopetrosis II (ADOII) is a relatively benign disorder caused by a missense mutation in the ClCN7 gene. In this study, we characterize the osteoclasts from patients with ADOII, caused by a G215R mutation, and investigate the effect on osteoclast function in vitro. Osteoclasts fr…

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