4 Publication(s) found
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Hepatic System, Non-Alcoholic Fatty Liver Disease
16. Oct 2019

Improvement of non-invasive markers of NAFLD from an individualised, web-based exercise program.

BACKGROUND:
Lifestyle modifications remain the cornerstone of treatment in non-alcoholic fatty liver disease (NAFLD). However, they requently fail related to the inability of patients to implement lasting changes.

AIMS:
To evaluate the effects of a short, web-based, individualised exercise prog…

Gastrointestinal, Inflammatory Bowel Disease
8. May 2017

Misbalance in type III collagen formation/degradation as a novel serological biomarker for penetrating (Montreal B3) Crohn's disease

BACKGROUND:
Misbalances in extracellular matrix turnover are key factors in the development of stricturing (Montreal B2) and penetrating (Montreal B3) Crohn's disease.

AIM:
To determine whether serological markers for collagen formation and degradation could serve as biomarkers for complication…

Hepatic System, Hepatitis B/C, Extracellular Matrix Research
3. Oct 2016

Fibrosis is not just fibrosis - basement membrane modelling and collagen metabolism differs between hepatitis B- and C-induced injury

BACKGROUND:
While morphological patterns differ, the molecular phenotype of liver fibrosis is considered a stereotypical response to chronic liver injury. However, with different cellular triggers and networks regulating fibrosis, the molecular responses of the injured liver may not be identical.

Extracellular Matrix Research, Hepatic System
5. Aug 2014

Review article: the efficacy of biomarkers in chronic fibroproliferative diseases - early diagnosis and prognosis, with liver fibrosis as an exemplar

BACKGROUND:
Nearly 45% of all deaths are associated with chronic fibroproliferative diseases, of which the primary characteristic is altered remodelling of the extracellular matrix. A major difficulty in developing anti-fibrotic therapies is the lack of accurate and established techniques to estima…