Hepatic System, Hepatitis B/C
3. Sep 2018
A STAT4 variant increases liver fibrosis risk in Caucasian patients with chronic hepatitis B.
BACKGROUND:
Host genetic modifiers of the natural history of chronic hepatitis B (CHB) remain poorly understood. Recently, a genome-wide association study (GWAS)-identified polymorphism in the STAT4 gene that contributes to the risk for hepatocellular carcinoma (HCC) was shown to be associated with…
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Journal:
Authors:
- El Sharkawy R,
- Thabet K,
- Lampertico P,
- Petta S,
- Mangia A,
- Berg T,
- Netwally M,
- Bayoumi A,
- Boonstra A,
- Brouwer WP,
- Smedile A,
- Abate ML,
- Loglio A,
- Douglas MW,
- Khan A,
- Santoro R,
- Fischer J,
- Leeming DJ,
- Liddle C,
- George J,
- Eslam M,
Hepatic System, Alcoholic Liver Disease
5. Nov 2013
Novel serological neo-epitope markers of extracellular matrix proteins for the detection of portal hypertension
BACKGROUND:
The hepatic venous pressure gradient (HVPG) is an invasive, but important diagnostic and prognostic marker in cirrhosis with portal hypertension (PHT). During cirrhosis, remodelling of fibrotic tissue by matrix metalloproteinases (MMPs) is a permanent process generating small fragments …
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Journal:
Authors:
- Leeming D,
- Karsdal MA,
- Bendtsen F,
- Trebicka J,
- Nielsen MJ,
- Christiansen C,
- Møller S,
- Krag A,