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Bone, Biomarkers
22. Oct 2021

The Efficacy and Safety of Multiple Dose Regimens of Kudzu ( Pueraria lobata) Root Extract on Bone and Cartilage Turnover and Menopausal Symptoms

ABSTRACT
Background: Menopause is associated with detrimental changes in turnover of bone and cartilage and a variety of symptoms with negative impact on the quality of life. Naturally occurring isoflavones from Radix Pueraria lobata, Kudzu root, may possess chondroprotective and symptom-relieving …

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Biomarkers
1. Oct 2021

A biomarker perspective on the acute effect of exercise with and without impact on joint tissue turnover: an exploratory randomized cross-over study

ABSTRACT
Purpose: To investigate acute changes in biochemical markers of bone and cartilage turnover in response to moderate intensity exercise with and without joint impact in healthy human subjects.

Methods: A randomized, cross-over, exploratory, clinical study was conducted. Twenty healthy su…

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Rheumatology, Osteoarthritis, Biomarkers
1. Jul 2021

Does moderate intensity impact exercise and non-impact exercise induce acute changes in collagen biochemical markers related to osteoarthritis? - An exploratory randomized cross-over trial

ABSTRACT
Objective: To investigate acute changes in biochemical markers of cartilage turnover in response to moderate intensity exercise with and without joint impact in humans with knee osteoarthritis.

Design: We conducted a randomized, cross-over, exploratory clinical study. Twenty subjects wi…

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Rheumatology, Osteoarthritis, Biomarkers, Rheumatoid Arthritis
22. Mar 2021

Serum C-reactive protein metabolite (CRPM) is associated with incidence of contralateral knee osteoarthritis

ABSTRACT
The heterogeneous nature of osteoarthritis (OA) and the need to subtype patients is widely accepted in the field. The biomarker CRPM, a metabolite of C-reactive protein (CRP), is released to the circulation during inflammation. Blood CRPM levels have shown to be associated with disease act…

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Rheumatology, Osteoarthritis, Biomarkers
1. Jun 2020

Evaluation of serum ARGS neoepitope as an osteoarthritis biomarker using a standardized model for exercise-induced cartilage extra cellular matrix turnover

OBJECTIVE
To propose a standardized model for exercise-induced cartilage turnover and investigate residual levels and dynamics of biomarker serum ARGS (sARGS) in primary osteoarthritis (OA) patients and a supportive group of young healthy subjects.

METHOD
The trial is a randomized, cross-over, …

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Rheumatology, Osteoarthritis, Biomarkers
15. Mar 2020

The acute and long-term impact of physical activity on biochemical markers and MRI measures in osteoarthritis - Perspectives for clinical osteoarthritis research

We aimed to investigate existing literature on the impact of physical activity and exercise (PA) on joint biochemical markers (BM) and magnetic resonance imaging (MRI) outcomes in osteoarthritis (OA), and on this basis propose directions for future research. Literature Review. Original papers were i…

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Rheumatology, Osteoarthritis, Biomarkers
3. Sep 2019

Associations between biomarkers of bone and cartilage turnover, gender, pain categories and radiographic severity in knee osteoarthritis.

ABSTRACT
Background: Excessive cartilage degradation is a known characteristic of osteoarthritis (OA). Biochemical markers, such as uCTX-II, have been shown to be associated with disease severity, yet the tissue origin of CTX-II has been disputed. This analysis investigates the association between …

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Rheumatology, Osteoarthritis, Biomarkers
6. Jan 2019

Protein biomarkers associated with pain mechanisms in osteoarthritis

ABSTRACT
Background: Osteoarthritis (OA) is the most common arthritic disease in the world, leading to debilitating pain and destruction of joint tissues. While pain is the hallmark symptom of osteoarthritis, clear associations between pain and disease processes involved in joint deterioration are …

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Authors:

  • Thudium CS,
  • Löfvall H,
  • Karsdal MA,
  • Bay-Jensen AC,
  • Bihlet AR,
Extracellular Matrix Research, Biomarkers
29. Mar 2018

Matrix Metalloproteinase Mediated Type I Collagen Degradation is an Independent Predictor of Increased Risk of Acute Myocardial Infarction in Postmenopausal Women

ABSTRACT
Chronic fibro-proliferative diseases are associated with nearly 45% of all deaths in the developed world. Matrix metalloproteinase (MMP) mediated remodeling of the extracellular matrix (ECM) plays an important role in disease development. Degradation of type I collagen is considered having…

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Authors:

  • Bertelsen DM,
  • Neergaard JS,
  • Bager CL,
  • Nielsen SH,
  • Secher NH,
  • Svendsen JH,
  • Bihlet AR,
  • Andersen JR,
  • Karsdal MA,
  • Christiansen C,
  • Nielsen HB,
Biomarkers
4. Dec 2017

Biomarkers of collagen turnover are related to annual change in FEV1 in patients with chronic obstructive pulmonary disease within the ECLIPSE study

ABSTRACT
Background: Change in forced expiratory volume in one second (FEV1) is important for defining severity of chronic obstructive pulmonary disease (COPD). Serological neoepitope markers of collagen turnover may predict rate of change in FEV1.

Methods: One thousand COPD subjects from the ob…

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Authors:

  • Leeming DJ,
  • Byrjalsen I,
  • Sand JMB,
  • Bihlet AR,
  • Lange P,
  • Evaluation of COPD Longitudinally to Identify Surrogate Endpoints (ECLIPSE) study investigators,
  • Thal-Singer R,
  • Miller BE,
  • Karsdal MA,
  • Vestbo J,
Biomarkers, Extracellular Matrix Research
19. Jan 2017

Biomarkers of extracellular matrix turnover are associated with emphysema and eosinophilic-bronchitis in COPD

ABSTRACT
Background: Chronic obstructive pulmonary disease (COPD) is characterized by airflow obstruction and loss of lung tissue mainly consisting of extracellular matrix (ECM). Three of the main ECM components are type I collagen, the main constituent in the interstitial matrix, type VI collagen,…

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Authors:

  • Bihlet AR,
  • Karsdal MA,
  • Sand JM,
  • Leeming DJ,
  • Roberts M,
  • Bowler R,
  • White W,
Rheumatology, Osteoarthritis, Biomarkers
2. Dec 2016

Disease-modifying treatments for osteoarthritis (DMOADs) of the knee and hip: lessons learned from failures and opportunities for the future

ABSTRACT
Osteoarthritis (OA) is the biggest unmet medical need among the many musculoskeletal conditions and the most common form of arthritis. It is a major cause of disability and impaired quality of life in the elderly. We review several ambitious but failed attempts to develop joint structure-m…

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Authors:

  • Karsdal MA,
  • Michaelis M,
  • Ladel C,
  • Siebuhr AS,
  • Bihlet AR,
  • Andersen JR,
  • Guehring H,
  • Christiansen C,
  • Bay-Jensen AC,
  • Kraus VB,
Biomarkers, Extracellular Matrix Research
4. Oct 2016

High levels of biomarkers of collagen remodeling are associated with increased mortality in COPD - results from the ECLIPSE study

ABSTRACT
Background: There is a need to identify individuals with COPD at risk for disease progression and mortality. Lung tissue remodeling is associated with the release of extracellular matrix (ECM) fragments into the peripheral circulation. We hypothesized that ECM remodeling was associated wit…

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Authors:

  • Sand JM,
  • Leeming DJ,
  • Byrjalsen I,
  • Bihlet AR,
  • Lange P,
  • Tal-Singer R,
  • Miller BE,
  • Karsdal MA,
  • Vestbo J,
Biomarkers, Clinical Data Quality
1. Jul 2015

Clinical Drug Development Using Dynamic Biomarkers to Enable Personalized Health Care in COPD

ABSTRACT
Despite massive investments in the development of novel treatments for heterogeneous diseases such as COPD, the resources spent have only benefited a fraction of the population treated. Personalized health care to guide selection of a suitable patient population already in the clinical dev…

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Authors:

  • Bihlet AR,
  • Karsdal MA,
  • Bay-Jensen AC,
  • Read S,
  • Kristensen JH,
  • Sand JM,
  • Leeming DJ,
  • Andersen JR,
  • Lange P,
  • Vestbo J,