Rheumatology, Osteoarthritis, Clinical Data Quality
8. Oct 2019
Effect of Intra-Articular Sprifermin vs Placebo on Femorotibial Joint Cartilage Thickness in Patients With Osteoarthritis: The FORWARD Randomized Clinical Trial.
ABSTRACT
Importance: Sprifermin is under investigation as a disease-modifying osteoarthritis drug.
Objective: To evaluate the effects of sprifermin on changes in total femorotibial joint cartilage thickness in the more symptomatic knee of patients with osteoarthritis.
Design, setting, and par…
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Journal:
Authors:
- Hochberg MC,
- Guermazi A,
- Guehring H,
- Aydemir A,
- Wax S,
- Fleuranceau-Morel P,
- Bihlet AR,
- Byrjalsen I,
- Andersen JR,
- Eckstein F,
Rheumatology, Osteoarthritis, Biomarkers
3. Sep 2019
Associations between biomarkers of bone and cartilage turnover, gender, pain categories and radiographic severity in knee osteoarthritis.
ABSTRACT
Background: Excessive cartilage degradation is a known characteristic of osteoarthritis (OA). Biochemical markers, such as uCTX-II, have been shown to be associated with disease severity, yet the tissue origin of CTX-II has been disputed. This analysis investigates the association between …
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Journal:
Authors:
- Bihlet AR,
- Byrjalsen I,
- Bay-Jensen AC,
- Andersen JR,
- Christiansen C,
- Riis BJ,
- Karsdal MA,
Rheumatology, Osteoarthritis
26. Jun 2019
Incidence of total hip and total knee replacements from the prospective epidemiologic risk factor study: considerations for event driven clinical trial design
ABSTRACT
Background: Osteoarthritis (OA) leads to joint failure and total joint replacement (TJR, either hip (H) or knee (K)). Worsening of pain and joint space narrowing are believed to be surrogates for joint failure; however, we hypothesize that TJR, as a reflection of joint failure, can be used…
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Journal:
Authors:
- Bager CL,
- Karsdal MA,
- Bihlet AR,
- Thudium CS,
- Byrjalsen I,
- Bay-Jensen AC,
Rheumatology, Osteoarthritis, Biomarkers
6. Jan 2019
Protein biomarkers associated with pain mechanisms in osteoarthritis
ABSTRACT
Background: Osteoarthritis (OA) is the most common arthritic disease in the world, leading to debilitating pain and destruction of joint tissues. While pain is the hallmark symptom of osteoarthritis, clear associations between pain and disease processes involved in joint deterioration are …
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Journal:
Authors:
- Thudium CS,
- Löfvall H,
- Karsdal MA,
- Bay-Jensen AC,
- Bihlet AR,