Rheumatology, Osteoarthritis
11. Dec 2014
Association between experimental pain biomarkers and serologic markers in patients with different degrees of painful knee osteoarthritis
OBJECTIVE:
To assess the association between pain mechanisms (sensitization) and biochemical markers for cartilage, bone, and inflammation in patients with knee pain.
METHODS:
The study group comprised 281 patients with different degrees of knee pain intensity and radiographic findings (using t…
Read the publication
Journal:
Authors:
- Arendt-Nielsen L,
- Eskehave TN,
- Egsgaard LL,
- Petersen KK,
- Graven-Nielsen T,
- Hoeck HC,
- Simonsen O,
- Siebuhr AS,
- Karsdal MA,
- Bay-Jensen AC,
Rheumatology, Osteoarthritis
4. Dec 2014
Suitability Of Nitisinone In Alkaptonuria 1 (SONIA 1): an international, multicentre, randomised, open-label, no-treatment controlled, parallel-group, dose-response study to investigate the effect of once daily nitisinone on 24-h urinary homogentisic acid excretion in patients with alkaptonuria after 4 weeks of treatment
BACKGROUND:
Alkaptonuria (AKU) is a serious genetic disease characterised by premature spondyloarthropathy. Homogentisate-lowering therapy is being investigated for AKU. Nitisinone decreases homogentisic acid (HGA) in AKU but the dose-response relationship has not been previously studied.
METHOD…
Read the publication
Journal:
Authors:
- Ranganath LR,
- Milan AM,
- Hughes AT,
- Dutton JJ,
- Fitzgerald R,
- Briggs MC,
- Bygott H,
- Psarelli EE,
- Cox TF,
- Gallagher JA,
- Jarvis JC,
- van Kan C,
- Hall AK,
- Laan D,
- Olsson B,
- Szamosi J,
- Rudebeck M,
- Kullenberg T,
- Cronlund A,
- Svensson L,
- Junestrand C,
- Ayoob H,
- Timmis OG,
- Sireau N,
- Le Quan Sang KH,
- Genovese F,
- Braconi D,
- Santucci A,
- Nemethova M,
- Zatkova A,
- McCaffrey J,
- Christensen P,
- Ross G,
- Imrich R,
- Rovensky J,
Osteoarthritis, Rheumatology
17. Oct 2014
Cartilage turnover reflected by metabolic processing of type II collagen: a novel marker of anabolic function in chondrocytes
The aim of this study was to enable measurement of cartilage formation by a novel biomarker of type II collagen formation. The competitive enzyme-linked immunosorbent assay (ELISA) Pro-C2 was developed and characterized for assessment of the beta splice variant of type II procollagen (PIIBNP). This …
Read the publication
Journal:
Authors:
- Gudmann NS,
- Wang J,
- Hoielt S,
- Chen P,
- Siebuhr AS,
- He Y,
- Christiansen TG,
- Karsdal MA,
- Bay-Jensen AC,
Osteoarthritis
1. Sep 2014
Alpha C-telopeptide of type I collagen is associated with subchondral bone turnover and predicts progression of joint space narrowing and osteophytes in osteoarthritis
OBJECTIVE:
To evaluate joint tissue remodeling using the urinary collagen biomarkers urinary α-C-telopeptide of type I collagen (α-CTX) and urinary C-telopeptide of type II collagen (CTX-II) and to determine the association of these biomarkers with osteoarthritis (OA) severity, progression, and loc…
Read the publication
Journal:
Authors:
- Huebner JL,
- Bay-Jensen AC,
- Huffman K,
- He Y,
- Leeming DJ,
- McDaniel GE,
- Karsdal MA,
- Kraus VB,
Rheumatology, Osteoarthritis
28. Aug 2014
Association Between Experimental Pain Biomarkers and Serological Markers in Patients With Different Degree of Painful Knee Osteoarthritis
OBJECTIVE:
To assess the association between pain mechanisms (sensitization) and biochemical markers for cartilage, bone, and inflammation in patients with knee pain.
METHODS:
The study group comprised 281 patients with different degrees of knee pain intensity and radiographic findings (using t…
Read the publication
Journal:
Authors:
- Arendt-Nielsen L,
- Eskehave TN,
- Egsgaard LL,
- Petersen KK,
- Graven-Nielsen T,
- Hoeck HC,
- Simonsen O,
- Siebuhr AS,
- Karsdal MA,
- Bay-Jensen AC,
Rheumatology, Osteoarthritis
1. Aug 2014
Biomarkers of cartilage and surrounding joint tissue
The identification and clinical demonstration of efficacy and safety of osteo- and chondro-protective drugs are met with certain difficulties. During the last few decades, the pharmaceutical industry has, in the field of rheumatology, experienced disappointments associated with the development of di…
Read the publication
Journal:
Authors:
- Siebuhr AS,
- He Y,
- Gudmann NS,
- Gram A,
- Kjelgaard-Petersen CF,
- Qvist P,
- Karsdal MA,
- Bay-Jensen AC,
Rheumatology, Osteoarthritis
23. Jul 2014
Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance
BACKGROUND:
Research for the use of biomarkers in osteoarthritis (OA) is promising, however, adequate discrimination between patients and controls may be hampered due to innate differences. We set out to identify loci influencing levels of serum cartilage oligomeric protein (sCOMP) and urinary C-te…
Read the publication
Journal:
Authors:
- Ramos YF,
- Metrustry S,
- Arden NK,
- Bay-Jensen AC,
- Beekman M,
- de Craen AJ,
- Cupples LA,
- Esko T,
- Evangelou E,
- Felson DT,
- Hart DJ,
- Ioannidis JP,
- Karsdal MA,
- Kloppenburg M,
- Lafeber F,
- Metspalu A,
- Panoutsopoulou K,
- Slagboom PE,
- Spector TD,
- van Spil EW,
- Uitterlinden AG,
- Zhu Y,
- Valdes AM,
- van Meurs JB,
- Meulenbelt I,
Bone, Rheumatology, Osteoarthritis
6. Jun 2014
ALPHA-CTX is associated with subchondral bone turnover and predicts progression of joint space narrowing and osteophytes in osteoarthritis
OBJECTIVE:
To evaluate joint tissue remodeling, with urinary collagen biomarkers, uALPHA CTX and uCTXII, and their association with osteoarthritis (OA) severity, progression, and localized knee bone turnover.
METHODS:
Participants (N=149) with symptomatic and radiographic knee OA underwent fixe…
Read the publication
Journal:
Authors:
- Huebner JL,
- Bay-Jensen AC,
- Huffman KM,
- He Y,
- Leeming DJ,
- McDaniel GE,
- Karsdal MA,
- Kraus VB,
Osteoarthritis
22. May 2014
Large scale meta-analysis of urinary C-terminal telopeptide, serum cartilage oligomeric protein and matrix metalloprotease degraded type II collagen and their role in prevalence, incidence and progression of osteoarthritis
OBJECTIVE:
To evaluate the role of three cartilage-derived biomarkers on osteoarthritis (OA): urinary C-terminal telopeptide (uCTX-II), serum cartilage oligomeric protein (sCOMP), and serum MMP degraded type II collagen (sC2M).
SUBJECTS AND METHODS:
Samples from 3582 individuals from the Rotter…
Read the publication
Journal:
Authors:
- Valdes AM,
- Meulenbelt I,
- Chassaing E,
- Arden NK,
- Bierma-Zeinstra S,
- Hart D,
- Hofman A,
- Karsdal MA,
- Kloppenburg M,
- Kroon HM,
- Slagboom EP,
- Spector TD,
- Uitterlinden AG,
- van Meurs JB,
- Bay-Jensen AC,
Osteoarthritis
19. Mar 2014
The active form of MMP-3 is a marker of synovial inflammation and cartilage turnover in inflammatory joint diseases
BACKGROUND:
Matrix metalloproteinase-3 (MMP-3) plays an important role in the pathology of rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Measurement of active MMP-3 in clinical samples could provide information about progression of rheumatoid diseases, and potentially response to treat…
Read the publication
Journal:
Authors:
- Sun S,
- Bay-Jensen AC,
- Karsdal MA,
- Siebuhr AS,
- Zheng Q,
- Maksymowych WP,
- Christiansen TG,
- Henriksen K,
Rheumatology, Osteoarthritis
1. Mar 2014
Republished: Value of biomarkers in osteoarthritis: current status and perspectives
Osteoarthritis affects the whole joint structure with progressive changes in cartilage, menisci, ligaments and subchondral bone, and synovial inflammation. Biomarkers are being developed to quantify joint remodelling and disease progression. This article was prepared following a working meeting of t…
Read the publication
Journal:
Authors:
- Lotz M,
- Martel-Pelletier J,
- Christiansen C,
- Brandi ML,
- Bruyère O,
- Chapurlat R,
- Collette J,
- Cooper C,
- Giacovelli G,
- Kanis JA,
- Karsdal MA,
- Kraus V,
- Lems WF,
- Meulenbelt I,
- Pelletier JP,
- Raynauld JP,
- Reiter-Niesert S,
- Rizzoli R,
- Sandell LJ,
- Van Spil WE,
- Reginster JY,
Rheumatology, Osteoarthritis
6. Feb 2014
The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments?
Osteoarthritis (OA) is the most common form of arthritic disease, and a major cause of disability and impaired quality of life in the elderly. OA is a complex disease of the entire joint, affecting bone, cartilage and synovium that thereby presents multiple targets for treatment. This manuscript wil…
Read the publication
Journal:
Authors:
- Karsdal MA,
- Bay-Jensen AC,
- Lories RJ,
- Abramson S,
- Spector T,
- Pastoureau P,
- Christiansen C,
- Attur M,
- Henriksen K,
- Goldring SR,
- Kraus V,
Rheumatology, Osteoarthritis
22. Jan 2014
Osteoarthritis--a case for personalized health care?
For both economic and ethical reasons, identification of the optimal treatment for each individual patient is a pressing concern, not only for the patients and their physician, but also health care payers and the pharmaceutical industry. In the field of osteoarthritis (OA) this is of particular rele…
Read the publication
Journal:
Authors:
- Karsdal MA,
- Christiansen C,
- Ladel C,
- Henriksen K,
- Kraus VB,
- Bay-Jensen AC,
Rheumatology, Osteoarthritis
7. Jan 2014
Identification and characterisation of osteoarthritis patients with inflammation derived tissue turnover
OBJECTIVES:
Osteoarthritis (OA) is a degenerative disease with a subset of patients experiencing joint inflammation, but C-reactive protein (CRP) has shown limited use in OA as a diagnostic marker. The aim was to identify subpopulations of patients with high or low levels of acute (high sensitive C…
Read the publication
Journal:
Authors:
- Siebuhr AS,
- Petersen KK,
- Arendt-Nielsen L,
- Egsgaard LL,
- Eskehave T,
- Christiansen C,
- Simonsen O,
- Hoeck HC,
- Karsdal MA,
- Bay-Jensen AC,