Rheumatology, Osteoarthritis
31. Aug 2008
Characterization of metalloprotease cleavage products of human articular cartilage
OBJECTIVE:
To identify, characterize, and compare proteolysis peptide products generated by metalloprotease digests of human articular cartilage.
METHODS:
Human articular cartilage was digested by the addition of exogenous metalloproteases, including matrix metalloproteinases 2, 3, 8, 9, 12, an…
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Journal:
Authors:
- Zhen EY,
- Brittain IJ,
- Laska DA,
- Mitchell PG,
- Sumer EU,
- Karsdal MA,
- Duffin KL,
Rheumatology, Osteoarthritis
16. Jun 2008
Should subchondral bone turnover be targeted when treating osteoarthritis?
OBJECTIVE:
Osteoarthritis (OA) is the most common form of arthritic disease, and it is a major cause of disability and impaired quality of life in the elderly. OA is a complex disease of the entire joint, including bone and cartilage, thereby presenting alternative approaches for treatment. This re…
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Authors:
- Karsdal MA,
- Leeming DJ,
- Dam EB,
- Henriksen K,
- Alexandersen P,
- Pastoureau P,
- Altman RD,
- Christiansen C,
Rheumatology, Osteoarthritis
6. Jun 2008
Automatic quantification of local and global articular cartilage surface curvature: biomarkers for osteoarthritis
The objective of this study was to quantitatively assess the surface curvature of the articular cartilage from low-field magnetic resonance imaging (MRI) data, and to investigate its role in populations with varying radiographic signs of osteoarthritis (OA), cross-sectionally and longitudinally. The…
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Journal:
Authors:
- Folkesson J,
- Dam EB,
- Olsen OF,
- Karsdal MA,
- Pettersen PC,
- Christiansen C,
Rheumatology, Osteoarthritis
8. May 2008
Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity
INTRODUCTION:
Physiological and pathophysiological cartilage turnover may coexist in articular cartilage. The distinct enzymatic processes leading to irreversible cartilage damage, compared with those needed for continuous self-repair and regeneration, remain to be identified. We investigated the c…
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Journal:
Authors:
- Karsdal MA,
- Madsen SH,
- Christiansen C,
- Henriksen K,
- Fosang AJ,
- Sondergaard BC,
Rheumatology, Osteoarthritis
10. Apr 2008
Oestrogen exhibits type II collagen protective effects and attenuates collagen-induced arthritis in rats
As anti-inflammatory treatments used in rheumatoid arthritis, such as glucocorticoids, often result in secondary detrimental effects on bone health, the objective of this study was to investigate the effects of oestrogen therapy (ET) on the development and activity of collagen-induced arthritis (CIA…
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Authors:
- Nielsen RH,
- Christiansen C,
- Stolina M,
- Karsdal MA,
Rheumatology, Osteoarthritis
13. Feb 2008
Evaluation of cartilage damage by measuring collagen degradation products in joint extracts in a traumatic model of osteoarthritis
The objective of this work was to investigate whether collagen degradation products in protein extract from joints could provide quantitative information on cartilage damage. Osteoarthritis (OA) was surgically induced in rat knee joints. Joints were isolated 7, 14 and 28 days after surgery for prote…
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Journal:
Authors:
- Nielsen RH,
- Stoop R,
- Leeming DJ,
- Stolina M,
- Qvist P,
- Christiansen C,
- Karsdal MA,
Rheumatology, Osteoarthritis
11. Feb 2008
An update review of cellular mechanisms conferring the indirect and direct effects of estrogen on articular cartilage
OBJECTIVE:
To review cellular mechanisms that have been proposed to mediate the indirect and direct effects of estrogen on articular cartilage, and to outline the remaining clinical questions that need to be clarified before utilizing the beneficial effects of estrogen for the prevention of osteoar…
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Journal:
Authors:
- Tankó LB,
- Søndergaard BC,
- Oestergaard S,
- Karsdal MA,
- Christiansen C,