Rheumatology, Osteoarthritis
14. Aug 2006
Calcitonin directly attenuates collagen type II degradation by inhibition of matrix metalloproteinase expression and activity in articular chondrocytes
OBJECTIVE:
Calcitonin was recently reported to counter progression of cartilage degradation in an experimental model of osteoarthritis, and the effects were primarily suggested to be mediated by inhibition of subchondral bone resorption. We investigated direct effects of calcitonin on chondrocytes …
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Journal:
Authors:
- Sondergaard BC,
- Wulf H,
- Henriksen K,
- Schaller S,
- Oestergaard S,
- Qvist P,
- Tankó LB,
- Bagger YZ,
- Christiansen C,
- Karsdal MA,
Rheumatology, Osteoarthritis
3. Aug 2006
Effects of ovariectomy and estrogen therapy on type II collagen degradation and structural integrity of articular cartilage in rats: implications of the time of initiation
OBJECTIVE:
To investigate how the time of initiation influences the effects of estrogen therapy on type II collagen (CII) turnover and the structural integrity of articular cartilage in ovariectomized rats and to determine whether estrogen exerts direct effects on the catabolic function of chondroc…
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Journal:
Authors:
- Oestergaard S,
- Sondergaard BC,
- Hoegh-Andersen P,
- Henriksen K,
- Qvist P,
- Christiansen C,
- Tankó LB,
- Karsdal MA,
Rheumatology, Osteoarthritis
14. Jul 2006
Calcitonin is involved in cartilage homeostasis: is calcitonin a treatment for OA?
OBJECTIVE:
Osteoarthritis (OA) is the most common form of degenerative joint diseases and a major cause of disability and impaired quality of life in the elderly. Recent observations suggest that calcitonin may act on both osteoclasts and chondrocytes. The present review was sought to summarize eme…
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Journal:
Authors:
- Karsdal MA,
- Tankó LB,
- Riis BJ,
- Sondergaard BC,
- Henriksen K,
- Altman RD,
- Qvist P,
- Christiansen C,
Rheumatology, Osteoarthritis
14. Jul 2006
The utility of measuring C-terminal telopeptides of collagen type II (CTX-II) in serum and synovial fluid samples for estimation of articular cartilage status in experimental models of destructive joint diseases
OBJECTIVE:
To characterize and validate a novel, enzyme-linked immunoassay for measuring cross-linked dimer forms of C-terminal telopeptides of type II collagen (CTX-II) in serum and synovial fluid of rodents, and investigate whether CTX-II measurements can reflect joint status in two established a…
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Journal:
Authors:
- Oestergaard S,
- Chouinard L,
- Doyle N,
- Karsdal MA,
- Smith SY,
- Qvist P,
- Tankó LB,
Rheumatology, Osteoarthritis
23. Mar 2006
Relative contribution of matrix metalloprotease and cysteine protease activities to cytokine-stimulated articular cartilage degradation
OBJECTIVE:
Both matrix metalloprotease (MMP) activity and cathepsin K (CK) activity have been implicated in cartilage turnover. We investigated the relative contribution of MMP activity and CK activity in cartilage degradation using ex vivo and in vivo models.
METHODS:
Bovine articular cartilag…
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Journal:
Authors:
- Søndergaard BC,
- Henriksen K,
- Wulf H,
- Oestergaard S,
- Schurigt U,
- Bräuer R,
- Danielsen I,
- Christiansen C,
- Qvist P,
- Karsdal MA,