Rheumatology, Osteoarthritis
1. Apr 2021
The effects of sprifermin on symptoms and structure in a subgroup at risk of progression in the FORWARD knee osteoarthritis trial
ABSTRACT
Objective: To assess pain outcomes and cartilage thickness change in a subgroup at risk (SAR) of further progression in the FORWARD trial of knee osteoarthritis patients treated with sprifermin.
Methods: Patients were randomised 1:1:1:1:1 to: sprifermin 100 µg every 6 months (q6mo), 100…
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Journal:
Authors:
- Guehring H,
- Moreau F,
- Daelken B,
- Ladel C,
- Guenther O,
- Bihlet AR,
- Wirth W,
- Eckstein F,
- Hochberg M,
- Conaghan PG,
Rheumatology, Osteoarthritis
15. Dec 2020
A novel diclofenac gel (AMZ001) applied once or twice daily in subjects with painful knee osteoarthritis: A randomized, placebo-controlled clinical trial
ABSTRACT
Purpose: Osteoarthritis Research Society International (OARSI) Expert Consensus Guidelines recommend topical non-steroidal anti-inflammatory drugs as first-line medications for osteoarthritis (OA) knee pain, but several voluminous daily applications are required to achieve efficacy. There …
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Journal:
Authors:
- Bihlet AR,
- Byrjalsen I,
- Simon LS,
- Carrara D,
- Delpy L,
- Derne C,
Rheumatology, Osteoarthritis, Clinical Data Quality
1. Dec 2020
Clinical and Biochemical Factors Associated With Risk of Total Joint Replacement and Radiographic Progression in Osteoarthritis: Data From Two Phase III Clinical Trials
ABSTRACT
Objectives: Clinical trials of new disease-modifying treatments for osteoarthritis should demonstrate a positive effect on a functional outcome or reduction in joint failure in order to be considered successful. Total joint replacement (TJR) surgery may be considered as joint failure, but …
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Journal:
Authors:
- Bihlet AR,
- Bjerre-Bastos JJ,
- Andersen JR,
- Byrjalsen I,
- Karsdal MA,
- Bay-Jensen AC,