Rheumatology, Osteoarthritis, Biomarkers, Rheumatoid Arthritis
22. Mar 2021
Serum C-reactive protein metabolite (CRPM) is associated with incidence of contralateral knee osteoarthritis
ABSTRACT
The heterogeneous nature of osteoarthritis (OA) and the need to subtype patients is widely accepted in the field. The biomarker CRPM, a metabolite of C-reactive protein (CRP), is released to the circulation during inflammation. Blood CRPM levels have shown to be associated with disease act…
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Journal:
Authors:
- Bay-Jensen AC,
- Bihlet AR,
- Byrjalsen I,
- Andersen JR,
- Riis BJ,
- Christiansen C,
- Michaelis M,
- Guehring H,
- Ladel C,
- Karsdal MA,
Rheumatology, Osteoarthritis, Extracellular Matrix Research, Clinical Data Quality
7. Apr 2020
Sprifermin (rhFGF18) Versus Vehicle Induces a Biphasic Process of Extracellular Matrix Remodeling in Human Knee OA Articular Cartilage Ex Vivo
ABSTRACT
Sprifermin, recombinant human fibroblast growth factor 18 (rhFGF18), induces cartilage regeneration in knees of patients with osteoarthritis (OA). We hypothesized that a temporal multiphasic process of extracellular matrix (ECM) degradation and formation underlie this effect. We aimed to c…
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Journal:
Authors:
- Reker D,
- Siebuhr AS,
- Thudium CS,
- Gantzel T,
- Ladel C,
- Michaelis M,
- Aspberg A,
- Berchtold MW,
- Karsdal MA,
- Gigout A,
- Bay-Jensen AC,