Rheumatology, Osteoarthritis
13. Oct 2011
Identification of the calcitonin receptor in osteoarthritic chondrocytes
BACKGROUND:
Preclinical and clinical studies have shown that salmon calcitonin has cartilage protective effects in joint degenerative diseases, such as osteoarthritis (OA). However, the presence of the calcitonin receptor (CTR) in articular cartilage chondrocytes is yet to be identified. In this st…
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Journal:
Authors:
- Segovia-Silvestre T,
- Bonnefond C,
- Sondergaard BC,
- Christensen T,
- Karsdal MA,
- Bay-Jensen AC,
Rheumatology, Osteoarthritis
15. Mar 2011
A microarray analysis of full depth knee cartilage of ovariectomized rats
BACKGROUND:
This short communication focuses the on articular cartilage and the subchondral bone, both of which play important roles in the development of osteoarthritis (OA). There are indications that estrogen-deficiency, as the post-menopausal state, accelerate the development of OA.
FINDINGS…
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Journal:
Authors:
- Bay-Jensen AC,
- Nielsen RH,
- Segovia-Silvestre T,
- Azria M,
- Staedtler F,
- Letzkus M,
- Hartmann N,
- Brachat AH,
- Karsdal MA,
Rheumatology, Osteoarthritis
18. Dec 2009
Suppression of MMP activity in bovine cartilage explants cultures has little if any effect on the release of aggrecanase-derived aggrecan fragments
Progressive loss of articular cartilage is a central hallmark in many joint disease, however, the relative importance of individual proteolytic pathways leading to cartilage erosion is at present unknown. We therefore investigated the time-dependant release ex vivo of MMP- and aggrecanase-derived fr…
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Journal:
Authors:
- Wang B,
- Chen P,
- Jensen AC,
- Karsdal MA,
- Madsen SH,
- Sondergaard BC,
- Zheng Q,
- Qvist P,