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Rheumatology, Osteoarthritis
4. Dec 2014

Suitability Of Nitisinone In Alkaptonuria 1 (SONIA 1): an international, multicentre, randomised, open-label, no-treatment controlled, parallel-group, dose-response study to investigate the effect of once daily nitisinone on 24-h urinary homogentisic acid excretion in patients with alkaptonuria after 4 weeks of treatment

BACKGROUND:
Alkaptonuria (AKU) is a serious genetic disease characterised by premature spondyloarthropathy. Homogentisate-lowering therapy is being investigated for AKU. Nitisinone decreases homogentisic acid (HGA) in AKU but the dose-response relationship has not been previously studied.

METHOD…

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Authors:

  • Ranganath LR,
  • Milan AM,
  • Hughes AT,
  • Dutton JJ,
  • Fitzgerald R,
  • Briggs MC,
  • Bygott H,
  • Psarelli EE,
  • Cox TF,
  • Gallagher JA,
  • Jarvis JC,
  • van Kan C,
  • Hall AK,
  • Laan D,
  • Olsson B,
  • Szamosi J,
  • Rudebeck M,
  • Kullenberg T,
  • Cronlund A,
  • Svensson L,
  • Junestrand C,
  • Ayoob H,
  • Timmis OG,
  • Sireau N,
  • Le Quan Sang KH,
  • Genovese F,
  • Braconi D,
  • Santucci A,
  • Nemethova M,
  • Zatkova A,
  • McCaffrey J,
  • Christensen P,
  • Ross G,
  • Imrich R,
  • Rovensky J,
Rheumatology, Osteoarthritis
17. Oct 2013

Metabolic health in families enriched for longevity is associated with low prevalence of hand osteoarthritis and influences OA biomarker profiles

OBJECTIVES:
Individual metabolic characteristics and age-related changes may affect osteoarthritis (OA) risk as well as levels of potential OA biomarkers such as serum cartilage oligomeric protein (sCOMP) and urinary cross-linked C-telopeptide of type 2 collagen (uCTX2). We investigated hand OA and…

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