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Hepatic System
25. Oct 2019

A Phase 1 Trial of Autologous Macrophage Therapy for Liver Cirrhosis

Therapies to reduce liver fibrosis and stimulate organ regeneration are urgently needed. We conducted a first-in-human, phase 1 dose-escalation trial of autologous macrophage therapy in nine adults with cirrhosis and a Model for End-Stage Liver Disease (MELD) score of 10-16 (ISRCTN 10368050). Groups…

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Authors:

  • Moroni F,
  • Dwyer BJ,
  • Graham C,
  • Pass C,
  • Bailey L,
  • Ritchie L,
  • Mitchell D,
  • Glover A,
  • Lauire A,
  • Doig S,
  • Hargreaves E,
  • Fraser AR,
  • Turner ML,
  • Cambpell JDM,
  • McGowan NWA,
  • Barry J,
  • Moore JK,
  • Hayes PC,
  • Leeming DJ,
  • Nielsen MJ,
  • Musa K,
  • Fallowfield JA,
  • Forbes SJ,
Rheumatology, Rheumatoid Arthritis
18. Apr 2018

Translational Biomarkers and Ex Vivo Models of Joint Tissues as a Tool for Drug Development in Rheumatoid Arthritis

OBJECTIVE:
Rheumatoid arthritis (RA) is a chronic, autoimmune and degenerative joint disease leading to disability, reduced life quality, and increased mortality. Although several synthetic and biological disease modifying anti-rheumatic drugs (DMARDs) are available, there is still a medical need f…

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Rheumatology, Gout
1. Jan 2015

Investigating the Robustness and Diagnostic Potential of Extracellular Matrix Remodelling Biomarkers in Alkaptonuria

BACKGROUND AND AIM:
Alkaptonuria (AKU) clinical manifestations resemble severe arthritis. The Suitability of Nitisinone in Alkaptonuria 1 (SONIA 1) study is a dose-finding trial for nitisinone treatment of AKU patients. We tested a panel of serum and urinary biomarkers reflecting extracellular matr…

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