Cardiovascular System, Central Nervous System
6. Nov 2019
A caspase-6-cleaved fragment of Glial Fibrillary Acidic Protein as a potential serological biomarker of CNS injury after cardiac arrest.
Blood levels of Glial Fibrillary Acidic protein (GFAP) reflect processes associated with different types of CNS injury. Evidence suggests that GFAP is cleaved by caspases during CNS injury, hence positioning GFAP fragments as potential biomarkers of injury-associated processes. We set out to develop…
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Authors:
- Jonesco DS,
- Hassager C,
- Frydland M,
- Kjærgaard J,
- Karsdal MA,
- Henriksen K,
Alzheimer’s Disease, Central Nervous System
11. May 2015
The potential of pathological protein fragmentation in blood-based biomarker development for dementia - with emphasis on Alzheimer's disease
The diagnosis of dementia is challenging and early stages are rarely detected limiting the possibilities for early intervention. Another challenge is the overlap in the clinical features across the different dementia types leading to difficulties in the differential diagnosis. Identifying biomarkers…
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Journal:
Authors:
- Inekci D,
- Jonesco DS,
- Kennard S,
- Karsdal MA,
- Henriksen K,