Biomarkers
1. Oct 2021
A biomarker perspective on the acute effect of exercise with and without impact on joint tissue turnover: an exploratory randomized cross-over study
ABSTRACT
Purpose: To investigate acute changes in biochemical markers of bone and cartilage turnover in response to moderate intensity exercise with and without joint impact in healthy human subjects.
Methods: A randomized, cross-over, exploratory, clinical study was conducted. Twenty healthy su…
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Journal:
Authors:
- Bjerre-Bastos JJ,
- Nielsen HB,
- Andersen JR,
- Karsdal MA,
- Boesen M,
- Mackey AL,
- Byrjalsen I,
- Thudium CS,
- Bihlet AR,
Rheumatology, Osteoarthritis, Biomarkers
1. Jul 2021
Does moderate intensity impact exercise and non-impact exercise induce acute changes in collagen biochemical markers related to osteoarthritis? - An exploratory randomized cross-over trial
ABSTRACT
Objective: To investigate acute changes in biochemical markers of cartilage turnover in response to moderate intensity exercise with and without joint impact in humans with knee osteoarthritis.
Design: We conducted a randomized, cross-over, exploratory clinical study. Twenty subjects wi…
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Journal:
Authors:
- Bjerre-Bastos JJ,
- Nielsen HB,
- Andersen JR,
- Karsdal MA,
- Bay-Jensen AC,
- Boesen M,
- Mackey AL,
- Byrjalsen I,
- Bihlet AR,
Rheumatology, Osteoarthritis, Clinical Data Quality
1. Dec 2020
Clinical and Biochemical Factors Associated With Risk of Total Joint Replacement and Radiographic Progression in Osteoarthritis: Data From Two Phase III Clinical Trials
ABSTRACT
Objectives: Clinical trials of new disease-modifying treatments for osteoarthritis should demonstrate a positive effect on a functional outcome or reduction in joint failure in order to be considered successful. Total joint replacement (TJR) surgery may be considered as joint failure, but …
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Journal:
Authors:
- Bihlet AR,
- Bjerre-Bastos JJ,
- Andersen JR,
- Byrjalsen I,
- Karsdal MA,
- Bay-Jensen AC,
Rheumatology, Osteoarthritis, Biomarkers
1. Jun 2020
Evaluation of serum ARGS neoepitope as an osteoarthritis biomarker using a standardized model for exercise-induced cartilage extra cellular matrix turnover
OBJECTIVE
To propose a standardized model for exercise-induced cartilage turnover and investigate residual levels and dynamics of biomarker serum ARGS (sARGS) in primary osteoarthritis (OA) patients and a supportive group of young healthy subjects.
METHOD
The trial is a randomized, cross-over, …
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Journal:
Authors:
- Bjerre-Bastos JJ,
- Nielsen HB,
- Andersen JR,
- He Y,
- Karsdal MA,
- Bay-Jensen AC,
- Boesen M,
- Mackey AL,
- Bihlet AR,
Rheumatology, Osteoarthritis, Biomarkers
15. Mar 2020
The acute and long-term impact of physical activity on biochemical markers and MRI measures in osteoarthritis - Perspectives for clinical osteoarthritis research
We aimed to investigate existing literature on the impact of physical activity and exercise (PA) on joint biochemical markers (BM) and magnetic resonance imaging (MRI) outcomes in osteoarthritis (OA), and on this basis propose directions for future research. Literature Review. Original papers were i…
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Journal:
Authors:
- Bjerre-Bastos JJ,
- Karsdal MA,
- Boesen M,
- Bliddal H,
- Bay-Jensen AC,
- Andersen JR,
- Bihlet AR,