Biomarkers
1. Oct 2021
A biomarker perspective on the acute effect of exercise with and without impact on joint tissue turnover: an exploratory randomized cross-over study
ABSTRACT
Purpose: To investigate acute changes in biochemical markers of bone and cartilage turnover in response to moderate intensity exercise with and without joint impact in healthy human subjects.
Methods: A randomized, cross-over, exploratory, clinical study was conducted. Twenty healthy su…
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Journal:
Authors:
- Bjerre-Bastos JJ,
- Nielsen HB,
- Andersen JR,
- Karsdal MA,
- Boesen M,
- Mackey AL,
- Byrjalsen I,
- Thudium CS,
- Bihlet AR,
Rheumatology, Osteoarthritis, Biomarkers
1. Jul 2021
Does moderate intensity impact exercise and non-impact exercise induce acute changes in collagen biochemical markers related to osteoarthritis? - An exploratory randomized cross-over trial
ABSTRACT
Objective: To investigate acute changes in biochemical markers of cartilage turnover in response to moderate intensity exercise with and without joint impact in humans with knee osteoarthritis.
Design: We conducted a randomized, cross-over, exploratory clinical study. Twenty subjects wi…
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Journal:
Authors:
- Bjerre-Bastos JJ,
- Nielsen HB,
- Andersen JR,
- Karsdal MA,
- Bay-Jensen AC,
- Boesen M,
- Mackey AL,
- Byrjalsen I,
- Bihlet AR,
Rheumatology, Osteoarthritis, Clinical Data Quality
1. Dec 2020
Clinical and Biochemical Factors Associated With Risk of Total Joint Replacement and Radiographic Progression in Osteoarthritis: Data From Two Phase III Clinical Trials
ABSTRACT
Objectives: Clinical trials of new disease-modifying treatments for osteoarthritis should demonstrate a positive effect on a functional outcome or reduction in joint failure in order to be considered successful. Total joint replacement (TJR) surgery may be considered as joint failure, but …
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Journal:
Authors:
- Bihlet AR,
- Bjerre-Bastos JJ,
- Andersen JR,
- Byrjalsen I,
- Karsdal MA,
- Bay-Jensen AC,